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In substituted sancycline compounds of the invention, R 4′ and R 4″ are each alkyl (eg, lower alkyl, eg, methyl); X is CR 6R 6′; and R 6, R 6′ and R 5 are each, generally, hydrogen! Are all T2 diabetics now being urged to take Lisiniprol or another ACE drug OR is this done when there is some indication that there IS kidney damage? Additionally, lubricating agents such as magnesium stearate, sodium lauryl sulfate and talc are often very useful for tabletting purposes?